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American Society of Microbiology ABMM Sample Questions:

1. A patient presents with a chronic, non-healing skin ulcer in a tropical region. Microscopic examination of a biopsy reveals amastigotes within macrophages. Culture of the biopsy on Novy-MacNeal-Nicolle (NNN) medium yields flagellated promastigotes. The MOST likely diagnosis is cutaneous leishmaniasis caused by:

A) Leishmania donovani
B) Trypanosoma cruzi
C) Leishmania tropica or Leishmania major
D) Trypanosoma brucei gambiense

2. A research laboratory is investigating the mechanism of action of a novel antiviral drug against herpes simplex virus. The drug is found to inhibit the viral DNA polymerase. Which of the following commercially available antiviral agents has a similar mechanism of action?

A) Oseltamivir
B) Acyclovir
C) Interferon-alpha
D) Amantadine

3. A patient with a prosthetic joint develops a chronic infection. Multiple synovial fluid cultures grow a Gram- positive coccus that forms a biofilm and is resistant to multiple antibiotics, including methicillin and gentamicin. The MOST likely organism is:

A) Staphylococcus epidermidis
B) Streptococcus agalactiae
C) Enterococcus faecium
D) Staphylococcus aureus

4. A patient develops a localized skin infection after being bitten by a tick. The infection is characterized by a slowly expanding erythematous rash with central clearing (erythema migrans). The MOST likely causative agent is:

A) Ehrlichia chaffeensis
B) Anaplasma phagocytophilum
C) Rickettsia rickettsii
D) Borrelia burgdorferi

5. A patient with HIV infection and a CD4+ T-cell count below 100 cells/µL presents with headache, fever, and altered mental status. CSF analysis reveals elevated protein and low glucose. India ink stain is negative.
Cryptococcal antigen test of the CSF is positive. The MOST appropriate initial treatment is:

A) Fluconazole
B) Caspofungin
C) Voriconazole
D) Amphotericin B and flucytosine

Solutions: